Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina

Thomas M. O'Hearn; Srinivas R. Sadda; James D. Weiland; Mauricio Maia; Eyal Margalit; Mark S. Humayun

doi:10.1016/j.visres.2006.03.031

Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina

Thomas M. O'Hearn, Srinivas R. Sadda, James D. Weiland, Mauricio Maia, Eyal Margalit, Mark S. Humayun

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Stimulus threshold and response latencies were measured for electrically elicited retinal ganglion cell responses in retina isolated from the eyes of normal and retinal degenerate (rd1) mice. Stimulation of the ganglion cell-side in normal retina yielded a significantly lower mean threshold and shorter latency when compared with stimulation of the photoreceptor side in normal retina. The latency of the ganglion cell-side stimulation in normal retina also proved to be significantly shorter than the latency for stimulation of the ganglion cell side in rd1 retina. Thus both the electrode positioning as well as the health of the retinal tissue play a role in the stimulating current required to elicit a retinal response.

Original language	English (US)
Pages (from-to)	3198-3204
Number of pages	7
Journal	Vision research
Volume	46
Issue number	19
DOIs	https://doi.org/10.1016/j.visres.2006.03.031
State	Published - Oct 2006
Externally published	Yes

Keywords

Electrophysiology
Mouse
rd1

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/j.visres.2006.03.031

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title = "Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina",

abstract = "Stimulus threshold and response latencies were measured for electrically elicited retinal ganglion cell responses in retina isolated from the eyes of normal and retinal degenerate (rd1) mice. Stimulation of the ganglion cell-side in normal retina yielded a significantly lower mean threshold and shorter latency when compared with stimulation of the photoreceptor side in normal retina. The latency of the ganglion cell-side stimulation in normal retina also proved to be significantly shorter than the latency for stimulation of the ganglion cell side in rd1 retina. Thus both the electrode positioning as well as the health of the retinal tissue play a role in the stimulating current required to elicit a retinal response.",

keywords = "Electrophysiology, Mouse, rd1",

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T1 - Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina

AU - O'Hearn, Thomas M.

AU - Sadda, Srinivas R.

AU - Weiland, James D.

AU - Maia, Mauricio

AU - Margalit, Eyal

AU - Humayun, Mark S.

PY - 2006/10

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AB - Stimulus threshold and response latencies were measured for electrically elicited retinal ganglion cell responses in retina isolated from the eyes of normal and retinal degenerate (rd1) mice. Stimulation of the ganglion cell-side in normal retina yielded a significantly lower mean threshold and shorter latency when compared with stimulation of the photoreceptor side in normal retina. The latency of the ganglion cell-side stimulation in normal retina also proved to be significantly shorter than the latency for stimulation of the ganglion cell side in rd1 retina. Thus both the electrode positioning as well as the health of the retinal tissue play a role in the stimulating current required to elicit a retinal response.

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KW - Mouse

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Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina

Abstract

Keywords

ASJC Scopus subject areas

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