Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina

Thomas M. O'Hearn, Srinivas R. Sadda, James D. Weiland, Mauricio Maia, Eyal Margalit, Mark S. Humayun

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Stimulus threshold and response latencies were measured for electrically elicited retinal ganglion cell responses in retina isolated from the eyes of normal and retinal degenerate (rd1) mice. Stimulation of the ganglion cell-side in normal retina yielded a significantly lower mean threshold and shorter latency when compared with stimulation of the photoreceptor side in normal retina. The latency of the ganglion cell-side stimulation in normal retina also proved to be significantly shorter than the latency for stimulation of the ganglion cell side in rd1 retina. Thus both the electrode positioning as well as the health of the retinal tissue play a role in the stimulating current required to elicit a retinal response.

Original languageEnglish (US)
Pages (from-to)3198-3204
Number of pages7
JournalVision research
Volume46
Issue number19
DOIs
StatePublished - Oct 2006

Keywords

  • Electrophysiology
  • Mouse
  • rd1

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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    O'Hearn, T. M., Sadda, S. R., Weiland, J. D., Maia, M., Margalit, E., & Humayun, M. S. (2006). Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina. Vision research, 46(19), 3198-3204. https://doi.org/10.1016/j.visres.2006.03.031