Electrohydrodynamic atomization for biodegradable polymeric particle production

Jingwei Xie, Liang Kuang Lim, Yiyong Phua, Jinsong Hua, Chi Hwa Wang

Research output: Contribution to journalArticlepeer-review

188 Scopus citations

Abstract

Electrohydrodynamic atomization (EHDA) has many applications such as electrospray ionization in mass spectroscopy, electrospray deposition of thin films, pharmaceutical productions, and polymeric particle fabrications for drug encapsulation. In the present study, EHDA was employed to produce biodegradable polymeric micro- and nanoparticles. The effects of processing parameters such as polymer concentration, flow rate, surfactants, organic salt, and setup configurations on the size and morphology of polymeric particles were investigated systematically. By changing the various processing parameters, controllable particle shape and size can be achieved. PLGA nanoparticles with size of around 250 nm can be obtained by using organic salts to increase the conductivity of the spraying solution even at a relatively high flow rate. A higher flow rate has the advantage of producing a stable cone spray and can be easily reproduced. Solid and porous particles can be fabricated using different experimental setups to control the organic solvent evaporation rate. Also, paclitaxel, a model antineoplastic drug, was encapsulated in polymeric particles which can be employed for controlled release applications. In short, EHDA is a promising technique to fabricate polymeric micro- or nanoparticles which can be used in drug delivery systems.

Original languageEnglish (US)
Pages (from-to)103-112
Number of pages10
JournalJournal of Colloid and Interface Science
Volume302
Issue number1
DOIs
StatePublished - Oct 1 2006

Keywords

  • Biodegradable
  • Electrohydrodynamic atomization
  • Microparticles
  • Nanoparticles
  • Polymeric

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

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