TY - JOUR
T1 - Electrospinning
T2 - An enabling nanotechnology platform for drug delivery and regenerative medicine
AU - Chen, Shixuan
AU - Li, Ruiquan
AU - Li, Xiaoran
AU - Xie, Jingwei
N1 - Funding Information:
This work was supported by grants from the National Institute of General Medical Science (NIGMS) at the NIH (2P20 GM103480-06 and 1R01GM123081), NE LB606 and startup funds from the University of Nebraska Medical Center.
Funding Information:
This work was supported by grants from the National Institute of General Medical Science (NIGMS) at the NIH ( 2P20 GM103480-06 and 1R01GM123081 ), NE LB606 and startup funds from the University of Nebraska Medical Center .
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/7
Y1 - 2018/7
N2 - Electrospinning provides an enabling nanotechnology platform for generating a rich variety of novel structured materials in many biomedical applications including drug delivery, biosensing, tissue engineering, and regenerative medicine. In this review article, we begin with a thorough discussion on the method of producing 1D, 2D, and 3D electrospun nanofiber materials. In particular, we emphasize on how the 3D printing technology can contribute to the improvement of traditional electrospinning technology for the fabrication of 3D electrospun nanofiber materials as drug delivery devices/implants, scaffolds or living tissue constructs. We then highlight several notable examples of electrospun nanofiber materials in specific biomedical applications including cancer therapy, guiding cellular responses, engineering in vitro 3D tissue models, and tissue regeneration. Finally, we finish with conclusions and future perspectives of electrospun nanofiber materials for drug delivery and regenerative medicine.
AB - Electrospinning provides an enabling nanotechnology platform for generating a rich variety of novel structured materials in many biomedical applications including drug delivery, biosensing, tissue engineering, and regenerative medicine. In this review article, we begin with a thorough discussion on the method of producing 1D, 2D, and 3D electrospun nanofiber materials. In particular, we emphasize on how the 3D printing technology can contribute to the improvement of traditional electrospinning technology for the fabrication of 3D electrospun nanofiber materials as drug delivery devices/implants, scaffolds or living tissue constructs. We then highlight several notable examples of electrospun nanofiber materials in specific biomedical applications including cancer therapy, guiding cellular responses, engineering in vitro 3D tissue models, and tissue regeneration. Finally, we finish with conclusions and future perspectives of electrospun nanofiber materials for drug delivery and regenerative medicine.
KW - 3D printing
KW - Drug delivery
KW - Electrospinning
KW - Nanofibers
KW - Regenerative medicine
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U2 - 10.1016/j.addr.2018.05.001
DO - 10.1016/j.addr.2018.05.001
M3 - Article
C2 - 29729295
AN - SCOPUS:85046881968
SN - 0169-409X
VL - 132
SP - 188
EP - 213
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
ER -