Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine

Shixuan Chen, Ruiquan Li, Xiaoran Li, Jingwei Xie

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

Electrospinning provides an enabling nanotechnology platform for generating a rich variety of novel structured materials in many biomedical applications including drug delivery, biosensing, tissue engineering, and regenerative medicine. In this review article, we begin with a thorough discussion on the method of producing 1D, 2D, and 3D electrospun nanofiber materials. In particular, we emphasize on how the 3D printing technology can contribute to the improvement of traditional electrospinning technology for the fabrication of 3D electrospun nanofiber materials as drug delivery devices/implants, scaffolds or living tissue constructs. We then highlight several notable examples of electrospun nanofiber materials in specific biomedical applications including cancer therapy, guiding cellular responses, engineering in vitro 3D tissue models, and tissue regeneration. Finally, we finish with conclusions and future perspectives of electrospun nanofiber materials for drug delivery and regenerative medicine.

Original languageEnglish (US)
Pages (from-to)188-213
Number of pages26
JournalAdvanced Drug Delivery Reviews
Volume132
DOIs
StatePublished - Jul 2018

Keywords

  • 3D printing
  • Drug delivery
  • Electrospinning
  • Nanofibers
  • Regenerative medicine

ASJC Scopus subject areas

  • Pharmaceutical Science

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