Elevated mutagen susceptibility in cultured lymphocytes of oral cancer patients

A. H. Trivedi, S. R. Bakshi, R. J. Jaju, B. J. Dave, S. G. Adhvaryu, D. D. Patel, D. B. Balar

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Mitomycin C (MMC)-induced lymphocytic sister chromatid exchange (SCE) frequency was studied in 40 oral cancer (OC) patients, 40 normal tobacco chewers (NC) and in 40 normal healthy individuals not consuming tobacco/areca nut in any form. Significantly higher MMC-induced SCE/cell values were observed among OC patients as compared to healthy nonchewer controls as well as NC. Although the mean SCE frequency for NC was comparable to that of healthy controls, three individuals showed an SCE rate higher than the highest observed among controls. The comparable frequency of the tobacco habit in these three individuals with that of the rest of the thirty-seven individuals indicated the possible involvement of factors other than tobacco consumption for the higher susceptibility to mutagens.

Original languageEnglish (US)
Pages (from-to)2589-2592
Number of pages4
JournalAnticancer Research
Volume15
Issue number6 B
StatePublished - 1995

Keywords

  • Lymphocytes
  • Mutagen susceptibility
  • Oral cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Trivedi, A. H., Bakshi, S. R., Jaju, R. J., Dave, B. J., Adhvaryu, S. G., Patel, D. D., & Balar, D. B. (1995). Elevated mutagen susceptibility in cultured lymphocytes of oral cancer patients. Anticancer Research, 15(6 B), 2589-2592.