Elevated mutagen susceptibility in cultured lymphocytes of oral cancer patients

A. H. Trivedi; S. R. Bakshi; R. J. Jaju; B. J. Dave; S. G. Adhvaryu; D. D. Patel; D. B. Balar

Elevated mutagen susceptibility in cultured lymphocytes of oral cancer patients

A. H. Trivedi, S. R. Bakshi, R. J. Jaju, B. J. Dave, S. G. Adhvaryu, D. D. Patel, D. B. Balar

Research output: Contribution to journal › Article › peer-review

Abstract

Mitomycin C (MMC)-induced lymphocytic sister chromatid exchange (SCE) frequency was studied in 40 oral cancer (OC) patients, 40 normal tobacco chewers (NC) and in 40 normal healthy individuals not consuming tobacco/areca nut in any form. Significantly higher MMC-induced SCE/cell values were observed among OC patients as compared to healthy nonchewer controls as well as NC. Although the mean SCE frequency for NC was comparable to that of healthy controls, three individuals showed an SCE rate higher than the highest observed among controls. The comparable frequency of the tobacco habit in these three individuals with that of the rest of the thirty-seven individuals indicated the possible involvement of factors other than tobacco consumption for the higher susceptibility to mutagens.

Original language	English (US)
Pages (from-to)	2589-2592
Number of pages	4
Journal	Anticancer Research
Volume	15
Issue number	6 B
State	Published - 1995
Externally published	Yes

Keywords

Lymphocytes
Mutagen susceptibility
Oral cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Elevated mutagen susceptibility in cultured lymphocytes of oral cancer patients",

abstract = "Mitomycin C (MMC)-induced lymphocytic sister chromatid exchange (SCE) frequency was studied in 40 oral cancer (OC) patients, 40 normal tobacco chewers (NC) and in 40 normal healthy individuals not consuming tobacco/areca nut in any form. Significantly higher MMC-induced SCE/cell values were observed among OC patients as compared to healthy nonchewer controls as well as NC. Although the mean SCE frequency for NC was comparable to that of healthy controls, three individuals showed an SCE rate higher than the highest observed among controls. The comparable frequency of the tobacco habit in these three individuals with that of the rest of the thirty-seven individuals indicated the possible involvement of factors other than tobacco consumption for the higher susceptibility to mutagens.",

keywords = "Lymphocytes, Mutagen susceptibility, Oral cancer",

author = "Trivedi, {A. H.} and Bakshi, {S. R.} and Jaju, {R. J.} and Dave, {B. J.} and Adhvaryu, {S. G.} and Patel, {D. D.} and Balar, {D. B.}",

year = "1995",

language = "English (US)",

volume = "15",

pages = "2589--2592",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Elevated mutagen susceptibility in cultured lymphocytes of oral cancer patients

AU - Trivedi, A. H.

AU - Bakshi, S. R.

AU - Jaju, R. J.

AU - Dave, B. J.

AU - Adhvaryu, S. G.

AU - Patel, D. D.

AU - Balar, D. B.

PY - 1995

Y1 - 1995

N2 - Mitomycin C (MMC)-induced lymphocytic sister chromatid exchange (SCE) frequency was studied in 40 oral cancer (OC) patients, 40 normal tobacco chewers (NC) and in 40 normal healthy individuals not consuming tobacco/areca nut in any form. Significantly higher MMC-induced SCE/cell values were observed among OC patients as compared to healthy nonchewer controls as well as NC. Although the mean SCE frequency for NC was comparable to that of healthy controls, three individuals showed an SCE rate higher than the highest observed among controls. The comparable frequency of the tobacco habit in these three individuals with that of the rest of the thirty-seven individuals indicated the possible involvement of factors other than tobacco consumption for the higher susceptibility to mutagens.

AB - Mitomycin C (MMC)-induced lymphocytic sister chromatid exchange (SCE) frequency was studied in 40 oral cancer (OC) patients, 40 normal tobacco chewers (NC) and in 40 normal healthy individuals not consuming tobacco/areca nut in any form. Significantly higher MMC-induced SCE/cell values were observed among OC patients as compared to healthy nonchewer controls as well as NC. Although the mean SCE frequency for NC was comparable to that of healthy controls, three individuals showed an SCE rate higher than the highest observed among controls. The comparable frequency of the tobacco habit in these three individuals with that of the rest of the thirty-seven individuals indicated the possible involvement of factors other than tobacco consumption for the higher susceptibility to mutagens.

KW - Lymphocytes

KW - Mutagen susceptibility

KW - Oral cancer

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