Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators

V. Wee Yong, Rana K. Zabad, Smriti Agrawal, Angelika Goncalves DaSilva, Luanne M. Metz

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


The matrix metalloproteinases (MMPs) are implicated in the pathology of multiple sclerosis (MS). This review summarizes the consequences of upregulation of MMP members in MS as well as in an animal model of the disease, experimental autoimmune encephalomyelitis (EAE). The pathogenic roles of MMPs are considered, especially in the transmigration of leukocytes into the CNS. We review the evidence that interferon-beta, an immunomodulator that is commonly used in MS, affects MMP expression in the disease. The potential of minocycline as a therapy in MS, based on its activity as an MMP inhibitor, is discussed. Besides affecting MMPs, minocycline may have other actions that help account for its possible utility in MS.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalJournal of the neurological sciences
Issue number1-2
StatePublished - Aug 15 2007
Externally publishedYes


  • EAE
  • Interferon-beta
  • Metalloproteinases
  • Minocycline
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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