Elevation of neutrophil chemotactic activity in the human serum and the decreased number of neutrophils after platelet-activating factor inhalation

H. Miyagawa, M. Nabe, R. J. Hopp, D. K. Agrawal, A. K. Bewtra, R. G. Townley

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Abstract

We previously reported a significant decrease in neutrophils at 5 min and an increased number of neutrophils at 15 min after PAF-acether inhalation. To investigate the mechanism, we measured the neutrophil chemotactic activity of the sera. Neutrophil chemotactic activity (NCA) of the serum at 5 min was greater than at baseline (p < 0.01) or at 15 min (p < 0.05). Furthermore, we investigated the correlation between the change in NCA and decreased number of neutrophils. A significant correlation was found between these two at 5 min (r = 0.751, p < 0.05). These data suggest that an elevation of NCA may play an important role in the decrease of circulating neutrophils after PAF-acether inhalation.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalInternational Archives of Allergy and Applied Immunology
Volume92
Issue number2
StatePublished - Jan 1 1990

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ASJC Scopus subject areas

  • Immunology and Allergy

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