@inproceedings{a0a7bbf5b6d743e4a9d2cd7b27b2edbf,
title = "Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models",
abstract = "Computational modeling of complex gene regulation among different mechanisms involving transcript factors, microRNAs, lncRNAs, epigenetic modification, in a chaotic disease system such as cancer, has posed unprecedented challenges. In this study, we introduce a new integrative framework that handles genomics data integration and network model fusion with focus on the inference of context-dependent microRNA-gene interactions. Using breast cancer as a case study, we have identified stage-specific microRNA-gene binding patterns. Functional analysis indicates microRNA regulated signaling during cancer progression.",
keywords = "Bayesian Network, Functional Analysis, Gaussian Process, Gene Regulatory Network, miRNA Binding",
author = "Haluk Dogan and Zeynep Hakguder and Stephen Scott and Juan Cui",
note = "Funding Information: * Corresponding author. This work has been supported by NIH-funded COBRE grant (1P20GM104320) and NIH [1R01 DK107264]/NIFA [2016-67001-06314].; 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 ; Conference date: 18-11-2019 Through 21-11-2019",
year = "2019",
month = nov,
doi = "10.1109/BIBM47256.2019.8983024",
language = "English (US)",
series = "Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "2729--2734",
editor = "Illhoi Yoo and Jinbo Bi and Hu, {Xiaohua Tony}",
booktitle = "Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019",
}