Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models

Haluk Dogan, Zeynep Hakguder, Stephen Scott, Juan Cui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Computational modeling of complex gene regulation among different mechanisms involving transcript factors, microRNAs, lncRNAs, epigenetic modification, in a chaotic disease system such as cancer, has posed unprecedented challenges. In this study, we introduce a new integrative framework that handles genomics data integration and network model fusion with focus on the inference of context-dependent microRNA-gene interactions. Using breast cancer as a case study, we have identified stage-specific microRNA-gene binding patterns. Functional analysis indicates microRNA regulated signaling during cancer progression.

Original languageEnglish (US)
Title of host publicationProceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
EditorsIllhoi Yoo, Jinbo Bi, Xiaohua Tony Hu
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2729-2734
Number of pages6
ISBN (Electronic)9781728118673
DOIs
StatePublished - Nov 2019
Externally publishedYes
Event2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 - San Diego, United States
Duration: Nov 18 2019Nov 21 2019

Publication series

NameProceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019

Conference

Conference2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
Country/TerritoryUnited States
CitySan Diego
Period11/18/1911/21/19

Keywords

  • Bayesian Network
  • Functional Analysis
  • Gaussian Process
  • Gene Regulatory Network
  • miRNA Binding

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Molecular Medicine
  • Modeling and Simulation
  • Health Informatics
  • Pharmacology (medical)
  • Public Health, Environmental and Occupational Health

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