Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models

Haluk Dogan; Zeynep Hakguder; Stephen Scott; Juan Cui

doi:10.1109/BIBM47256.2019.8983024

Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models

Haluk Dogan, Zeynep Hakguder, Stephen Scott, Juan Cui

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Computational modeling of complex gene regulation among different mechanisms involving transcript factors, microRNAs, lncRNAs, epigenetic modification, in a chaotic disease system such as cancer, has posed unprecedented challenges. In this study, we introduce a new integrative framework that handles genomics data integration and network model fusion with focus on the inference of context-dependent microRNA-gene interactions. Using breast cancer as a case study, we have identified stage-specific microRNA-gene binding patterns. Functional analysis indicates microRNA regulated signaling during cancer progression.

Original language	English (US)
Title of host publication	Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
Editors	Illhoi Yoo, Jinbo Bi, Xiaohua Tony Hu
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2729-2734
Number of pages	6
ISBN (Electronic)	9781728118673
DOIs	https://doi.org/10.1109/BIBM47256.2019.8983024
State	Published - Nov 2019
Externally published	Yes
Event	2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 - San Diego, United States Duration: Nov 18 2019 → Nov 21 2019

Publication series

Name	Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019

Conference

Conference	2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
Country/Territory	United States
City	San Diego
Period	11/18/19 → 11/21/19

Keywords

Bayesian Network
Functional Analysis
Gaussian Process
Gene Regulatory Network
miRNA Binding

ASJC Scopus subject areas

Biochemistry
Biotechnology
Molecular Medicine
Modeling and Simulation
Health Informatics
Pharmacology (medical)
Public Health, Environmental and Occupational Health

Access to Document

10.1109/BIBM47256.2019.8983024

Cite this

Dogan, H., Hakguder, Z., Scott, S., & Cui, J. (2019). Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models. In I. Yoo, J. Bi, & X. T. Hu (Eds.), Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 (pp. 2729-2734). Article 8983024 (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM47256.2019.8983024

Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models. / Dogan, Haluk; Hakguder, Zeynep; Scott, Stephen et al.
Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. ed. / Illhoi Yoo; Jinbo Bi; Xiaohua Tony Hu. Institute of Electrical and Electronics Engineers Inc., 2019. p. 2729-2734 8983024 (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Dogan, H, Hakguder, Z, Scott, S & Cui, J 2019, Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models. in I Yoo, J Bi & XT Hu (eds), Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019., 8983024, Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019, Institute of Electrical and Electronics Engineers Inc., pp. 2729-2734, 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019, San Diego, United States, 11/18/19. https://doi.org/10.1109/BIBM47256.2019.8983024

Dogan H, Hakguder Z, Scott S, Cui J. Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models. In Yoo I, Bi J, Hu XT, editors, Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 2729-2734. 8983024. (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019). doi: 10.1109/BIBM47256.2019.8983024

Dogan, Haluk ; Hakguder, Zeynep ; Scott, Stephen et al. / Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models. Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. editor / Illhoi Yoo ; Jinbo Bi ; Xiaohua Tony Hu. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 2729-2734 (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019).

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abstract = "Computational modeling of complex gene regulation among different mechanisms involving transcript factors, microRNAs, lncRNAs, epigenetic modification, in a chaotic disease system such as cancer, has posed unprecedented challenges. In this study, we introduce a new integrative framework that handles genomics data integration and network model fusion with focus on the inference of context-dependent microRNA-gene interactions. Using breast cancer as a case study, we have identified stage-specific microRNA-gene binding patterns. Functional analysis indicates microRNA regulated signaling during cancer progression.",

keywords = "Bayesian Network, Functional Analysis, Gaussian Process, Gene Regulatory Network, miRNA Binding",

author = "Haluk Dogan and Zeynep Hakguder and Stephen Scott and Juan Cui",

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Elucidation of MicroRNA-Gene Regulation in Human Cancer with Integrative Network Models

Abstract

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Keywords

ASJC Scopus subject areas

Access to Document

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