Abstract
Outbreaks of infection occur more often than they are reported in most developing countries, largely due to poor diagnostic services. A Klebsiella species bacteremia outbreak in a newborn unit with high mortality was recently encountered at a location being surveilled for childhood bacteremia. These surveillance efforts offered the opportunity to determine the cause of this neonatal outbreak. In this report, we present the whole-genome sequences of New Delhi metallo-β- lactamase (NDM-5)-containing Klebsiella quasipneumoniae subsp. similipneumoniae bloodstream isolates from a neonatal bacteremia outbreak at a tertiary hospital in Nigeria and as part of the largest collection of K. pneumoniae bloodstream isolates from children in Africa. Comparative analysis of the genetic environment surrounding the NDM-5 genes revealed nearly perfect sequence identity to bla NDM-5 -bearing IncX3-type plasmids from other members of the Enterobacteriaceae.
Original language | English (US) |
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Article number | e00685-18 |
Journal | mSphere |
Volume | 4 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1 2019 |
Keywords
- Antimicrobial resistance
- Bacteria
- Carbapenemase
- ESBL
- Enterobacteriaceae
- Klebsiella
- Neonate
- New Delhi metallo-β-lactamase (NDM-5)
- Nigeria
ASJC Scopus subject areas
- Microbiology
- Molecular Biology