Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials

Murielle Mimeault, Surinder K. Batra

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

The in vivo zebrafish models have recently attracted great attention in molecular oncology to investigate multiple genetic alterations associated with the development of human cancers and validate novel anticancer drug targets. Particularly, the transparent zebrafish models can be used as a xenotransplantation system to rapidly assess the tumorigenicity and metastatic behavior of cancer stem and/or progenitor cells and their progenies. Moreover, the zebrafish models have emerged as powerful tools for an in vivo testing of novel anticancer agents and nanomaterials for counteracting tumor formation and metastases and improving the efficacy of current radiation and chemotherapeutic treatments against aggressive, metastatic and lethal cancers.

Original languageEnglish (US)
Pages (from-to)128-140
Number of pages13
JournalDrug Discovery Today
Volume18
Issue number3-4
DOIs
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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