TY - JOUR
T1 - Emerging Roles of Electrospun Nanofibers in Cancer Research
AU - Chen, Shixuan
AU - Boda, Sunil Kumar
AU - Batra, Surinder K.
AU - Li, Xiaoran
AU - Xie, Jingwei
N1 - Funding Information:
This work was supported partially from startup funds from University of Nebraska Medical Center (UNMC), National Institute of General Medical Science (NIGMS) Grant No. 2P20 GM103480-06, National Institute of General Medical Science (NIGMS) of the National Institutes of Health under Award No. R01GM123081, and UNMC Regenerative Medicine Program pilot project Grant No. 37-1209-2004-007 and Otis Glebe Medical Research Foundation.
Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/3/21
Y1 - 2018/3/21
N2 - This article reviews the recent progress of electrospun nanofibers in cancer research. It begins with a brief introduction to the emerging potential of electrospun nanofibers in cancer research. Next, a number of recent advances on the important features of electrospun nanofibers critical for cancer research are discussed including the incorporation of drugs, control of release kinetics, orientation and alignment of nanofibers, and the fabrication of 3D nanofiber scaffolds. This article further highlights the applications of electrospun nanofibers in several areas of cancer research including local chemotherapy, combinatorial therapy, cancer detection, cancer cell capture, regulation of cancer cell behavior, construction of in vitro 3D cancer model, and engineering of bone microenvironment for cancer metastasis. This progress report concludes with remarks on the challenges and future directions for design, fabrication, and application of electrospun nanofibers in cancer diagnostics and therapeutics.
AB - This article reviews the recent progress of electrospun nanofibers in cancer research. It begins with a brief introduction to the emerging potential of electrospun nanofibers in cancer research. Next, a number of recent advances on the important features of electrospun nanofibers critical for cancer research are discussed including the incorporation of drugs, control of release kinetics, orientation and alignment of nanofibers, and the fabrication of 3D nanofiber scaffolds. This article further highlights the applications of electrospun nanofibers in several areas of cancer research including local chemotherapy, combinatorial therapy, cancer detection, cancer cell capture, regulation of cancer cell behavior, construction of in vitro 3D cancer model, and engineering of bone microenvironment for cancer metastasis. This progress report concludes with remarks on the challenges and future directions for design, fabrication, and application of electrospun nanofibers in cancer diagnostics and therapeutics.
KW - 3D cancer model
KW - Cancer detection
KW - Drug delivery
KW - Electrospun nanofibers
KW - Engineering bone microenvironment
KW - Regulation of cancer cell behavior
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U2 - 10.1002/adhm.201701024
DO - 10.1002/adhm.201701024
M3 - Article
C2 - 29210522
AN - SCOPUS:85037368407
SN - 2192-2640
VL - 7
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 6
M1 - 1701024
ER -