Emerging roles of MUC4 in cancer: A novel target for diagnosis and therapy

Ajay P. Singh, Pallavi Chaturvedi, Surinder K. Batra

Research output: Contribution to journalReview article

107 Scopus citations

Abstract

The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosis and prognosis. MUC4 modulates HER2/ErbB2 signaling and is a determinant of therapeutic outcome of Herceptin-based therapy, which further indicates its prospective usefulness in cancer therapy and treatment planning.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalCancer Research
Volume67
Issue number2
DOIs
StatePublished - Jan 15 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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