TY - JOUR
T1 - Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines
AU - Mallapragada, Surya K.
AU - Brenza, Timothy M.
AU - McMillan, Jo Ellyn M.
AU - Narasimhan, Balaji
AU - Sakaguchi, Donald S.
AU - Sharma, Anup D.
AU - Zbarska, Svitlana
AU - Gendelman, Howard E.
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015
Y1 - 2015
N2 - Nanoparticulate delivery systems represent an area of particular promise for nanoneuromedicines. They possess significant potential for desperately needed therapies designed to combat a range of disorders associated with aging. As such, the field was selected as the focus for the 2014 meeting of the American Society for Nanomedicine. Regenerative, protective, immune modulatory, anti-microbial and anti-inflammatory products, or imaging agents are readily encapsulated in or conjugated to nanoparticles and as such facilitate the delivery of drug payloads to specific action sites across the blood-brain barrier. Diagnostic imaging serves to precisely monitor disease onset and progression while neural stem cell replacement can regenerate damaged tissue through control of stem cell fates. These, taken together, can improve disease burden and limit systemic toxicities. Such enabling technologies serve to protect the nervous system against a broad range of degenerative, traumatic, metabolic, infectious and immune disorders.
AB - Nanoparticulate delivery systems represent an area of particular promise for nanoneuromedicines. They possess significant potential for desperately needed therapies designed to combat a range of disorders associated with aging. As such, the field was selected as the focus for the 2014 meeting of the American Society for Nanomedicine. Regenerative, protective, immune modulatory, anti-microbial and anti-inflammatory products, or imaging agents are readily encapsulated in or conjugated to nanoparticles and as such facilitate the delivery of drug payloads to specific action sites across the blood-brain barrier. Diagnostic imaging serves to precisely monitor disease onset and progression while neural stem cell replacement can regenerate damaged tissue through control of stem cell fates. These, taken together, can improve disease burden and limit systemic toxicities. Such enabling technologies serve to protect the nervous system against a broad range of degenerative, traumatic, metabolic, infectious and immune disorders.
KW - Drug development
KW - Nanoformulation
KW - Nanoneuromedicine
KW - Nanotechnology
KW - Targeting
UR - http://www.scopus.com/inward/record.url?scp=84933500494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84933500494&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2014.12.013
DO - 10.1016/j.nano.2014.12.013
M3 - Review article
C2 - 25652894
AN - SCOPUS:84933500494
SN - 1549-9634
VL - 11
SP - 715
EP - 729
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
IS - 3
ER -