Enamine Catalytic Annulation of Azonaphthalenes: An Access to Indole Derivatives

Hanhui Zhao, Huijun Yuan, Yanru Zhang, Rongshi Li, Wenjun Li

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The secondary-amine mediated [3 + 2] annulation of azonaphthalenes with aldehydes and ketones is described for the first time, which provides an alternative protocol for the synthesis of indole derivatives. It features a cheap and readily available catalyst, a broad scope of reactants, very mild reaction conditions, and high efficiency. Significantly different from the transition-metal-mediated processes, the enamine activation represents the first organic base-catalytic protocol for indole synthesis.

Original languageEnglish (US)
Pages (from-to)6557-6561
Number of pages5
JournalOrganic Letters
Issue number16
StatePublished - Aug 16 2019
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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