Enantiomeric synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate

Prabagaran Narayanasamy; Dean C. Crick

doi:10.3987/COM-08-S(N)72

Enantiomeric synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate

Prabagaran Narayanasamy, Dean C. Crick

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Enantiomerically pure 2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1 (ME-CPP) is synthesized from 1,2-O-isopropylidene-α-D-xylofuranose with facile phosphorylation in good yield. Subsequently, the synthesized enantiomerically pure 1 can be used as a substrate in IspG assays to identify inhibitors that may be developed into antibacterial drug leads.

Original language	English (US)
Pages (from-to)	243-247
Number of pages	5
Journal	Heterocycles
Volume	76
Issue number	1
DOIs	https://doi.org/10.3987/COM-08-S(N)72
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "Enantiomerically pure 2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1 (ME-CPP) is synthesized from 1,2-O-isopropylidene-α-D-xylofuranose with facile phosphorylation in good yield. Subsequently, the synthesized enantiomerically pure 1 can be used as a substrate in IspG assays to identify inhibitors that may be developed into antibacterial drug leads.",

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