Abstract
Enantiomerically pure 2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1 (ME-CPP) is synthesized from 1,2-O-isopropylidene-α-D-xylofuranose with facile phosphorylation in good yield. Subsequently, the synthesized enantiomerically pure 1 can be used as a substrate in IspG assays to identify inhibitors that may be developed into antibacterial drug leads.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 243-247 |
| Number of pages | 5 |
| Journal | Heterocycles |
| Volume | 76 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2008 |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry
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Cite this
Narayanasamy, P., & Crick, D. C. (2008). Enantiomeric synthesis of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate. Heterocycles, 76(1), 243-247. https://doi.org/10.3987/COM-08-S(N)72