Reduction of protected α-vinyl amino acids produces "neopentyl" alcohols that may be enriched in the L-antipode by lipase-mediated acylation with vinyl acetate. Subsequent deacetylation, oxidation and hydrolysis yields enantiomerically enriched L-α-vinyl amino acids.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Nov 21 1994|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry