Enantioselective alkylation of chiral enolates

D. A. Evans, J. M. Takacs

Research output: Contribution to journalArticlepeer-review

202 Scopus citations


Alkylations of chiral amide enolates derived from (ℓ)-prolinol have been shown to yield versatile hydroxy-amides in high diastereomeric purity. Their use in the preparation of optically active carboxylic acids is described.

Original languageEnglish (US)
Pages (from-to)4233-4236
Number of pages4
JournalTetrahedron Letters
Issue number44
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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