(Chemical Equation Presented) The use of N-H imide templates provides a solution to the problem of rotamer control in Lewis acid catalyzed reactions of α,β-disubstituted acryloyl imides. Reactions proceed through the s-cis rotamer and with improved reactivity because A1,3 strain is avoided. Enantioselective nitrone, nitrile oxide, and Diels-Alder cycloadditions demonstrate the principle.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jun 9 2005|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry