Abstract
The rhodium-catalyzed enantioselective desymmetrization of symmetric γ,δ-unsaturated amides via carbonyl-directed catalytic asymmetric hydroboration (directed CAHB) affords chiral secondary organoboronates with up to 98% ee. The chiral γ-borylated products undergo palladium-catalyzed Suzuki-Miyaura cross-coupling via the trifluoroborate salt with stereoretention.
Original language | English (US) |
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Pages (from-to) | 940-943 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 17 |
Issue number | 4 |
DOIs | |
State | Published - Feb 20 2015 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry