Five chiral 1,4-bis(oxazoline) ligands, each bearing a bicyclic backbone, were prepared and examined in Mg(OTf)2-, Zn(OTf)2, and Cu(OTf)2 catalyzed Diels-Alder reactions. The cycloadditions were carried out at room temperature and afforded enantiomeric excess up to 88%, Surprisingly, a non-C2-symmetric bis(oxazoline) bearing a meso backbone was among the more efficient ligands examined.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry