Endocannabinoids, metabolic regulation, and the role of diet

Timothy P. Carr, Elliot D. Jesch, Andrew W. Brown

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Understanding the endocannabinoid system as it relates to health and disease is a relatively new area of study. The discovery and cloning of cannabinoid receptors have prompted an increase in research aimed at identifying endogenous ligands ("endocannabinoids") and how these receptors and ligands regulate a variety of physiologic and pathologic events that include bone formation, the cardiovascular system, appetite control, and energy metabolism. With regard to nutrition, researchers have begun to ask whether the known effects of diet on metabolic processes are mediated through endocannabinoids and their receptors. Although only a few studies have been conducted that directly address the role of diet, results indicate that endocannabinoids can be regulated by eating frequency and by specific dietary components, particularly fatty acids. This review provides an overview of the endocannabinoid system and its control of metabolism, with emphasis on the impact of diet.

Original languageEnglish (US)
Pages (from-to)641-650
Number of pages10
JournalNutrition Research
Issue number10
StatePublished - Oct 2008


  • Bone
  • Cardiovascular
  • Dietary fats
  • Endocannabinoid receptors
  • Endocannabinoids
  • Energy metabolism
  • Metabolic regulation
  • Review

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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