Endocrine mechanisms, androgen receptor and carcinogenesis, and hormone escape

Kaustubh Datta, Donald J. Tindall

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Androgens play important roles during the development and maintenance of normal prostate as well as during the progression of prostate cancer. Testosterone, which is synthesized in the testes under the control of hormones from the pituitary and hypothalamus, is the primary androgen in men. Testosterone enters the prostate through blood stream and binds its cognate receptor (the androgen receptor or AR) in the acinar epithelial cells and the stromal cells. Like other nuclear hormone receptors, AR is a transcription factor, which is activated upon ligand binding in the cell cytoplasm. Activated AR enters the nucleus and regulates the transcription of genes involved in cell proliferation, survival, and differentiation. In this chapter, the endocrine mechanisms involve in the biosynthesis of androgen are discussed. Structural details of the androgen receptor, its changes in conformation upon ligand binding, various posttranslational modifications, and its coregulators are described. Specific roles of androgen/AR axis during the progression of prostate cancer and mechanisms by which AR activity is restored in prostate cancer cells of patients treated with androgen ablation therapy are discussed.

Original languageEnglish (US)
Title of host publicationProstate Cancer
Subtitle of host publicationA Comprehensive Perspective
PublisherSpringer-Verlag London Ltd
Pages35-41
Number of pages7
ISBN (Electronic)9781447128649
ISBN (Print)144712863X, 9781447128632
DOIs
StatePublished - Jul 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Datta, K., & Tindall, D. J. (2013). Endocrine mechanisms, androgen receptor and carcinogenesis, and hormone escape. In Prostate Cancer: A Comprehensive Perspective (pp. 35-41). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-2864-9_3