Endocrine/exocrine intermediate cells in streptozotocin-treated ins- IFN-γ transgenic mice

Danling Gu, Marc Arnush, Nora Sarvetnick

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


To trace the ontogeny of β cell regrowth in adult transgenic mice that produce interferon-γ in the islets (ins-IFN-γ), their existing β cells were depleted by treatment with high doses of streptozotocin (STZ). Initially, β cell necrosis and degranulation were apparent in STZ-treated mice of both the BALB/c and the ins-IFN-γ transgenic strains. The newly emerging transitional cells were then characterized by ultrastructural analysis. Interestingly, transitional cells harboring both exocrine and endocrine granules appeared frequently in ins-IFN-γ transgenics after high- dose STZ treatment. New β cells were produced primarily by the formation of new islets from the small pancreatic ducts. β cell regeneration in the ins- IFN-γ transgenic mouse model is thus explained primarily by the budding of new islets from the ducts with acinar cells as possible precursors of islet cells.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
Issue number3
StatePublished - Oct 1997
Externally publishedYes


  • Diabetes
  • Endocrine/exocrine intermediate cell
  • Ins-IFN-γ transgenie mice
  • Regeneration
  • Streptozotocin
  • β cells

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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