Abstract
To trace the ontogeny of β cell regrowth in adult transgenic mice that produce interferon-γ in the islets (ins-IFN-γ), their existing β cells were depleted by treatment with high doses of streptozotocin (STZ). Initially, β cell necrosis and degranulation were apparent in STZ-treated mice of both the BALB/c and the ins-IFN-γ transgenic strains. The newly emerging transitional cells were then characterized by ultrastructural analysis. Interestingly, transitional cells harboring both exocrine and endocrine granules appeared frequently in ins-IFN-γ transgenics after high- dose STZ treatment. New β cells were produced primarily by the formation of new islets from the small pancreatic ducts. β cell regeneration in the ins- IFN-γ transgenic mouse model is thus explained primarily by the budding of new islets from the ducts with acinar cells as possible precursors of islet cells.
Original language | English (US) |
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Pages (from-to) | 246-250 |
Number of pages | 5 |
Journal | Pancreas |
Volume | 15 |
Issue number | 3 |
DOIs | |
State | Published - Oct 1997 |
Externally published | Yes |
Keywords
- Diabetes
- Endocrine/exocrine intermediate cell
- Ins-IFN-γ transgenie mice
- Regeneration
- Streptozotocin
- β cells
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Hepatology
- Endocrinology