Endogenous Endophthalmitis

Duncan Berry, Steven Yeh

Research output: Chapter in Book/Report/Conference proceedingChapter


Endophthalmitis is a severe eye infection that can have severe vision-threatening complications. Endophthalmitis is usually caused by an exogenous source but may also be classified as endogenous as a result of hematogenous spread of a systemic infection. Endogenous endophthalmitis is often a diagnostic challenge and requires a high index of suspicion and a multidisciplinary approach. The causative microorganism may be bacterial or fungal, and appropriate and timely diagnosis and management frequently requires hospitalization. Both systemic and intravitreal antimicrobials are often necessary, and pars plana vitrectomy may be employed depending on the severity of the disease. Outcomes are generally poor but vary based on the disease duration, severity, and virulence of the offending pathogen. There are no established guidelines for the ideal management of these cases. This chapter will review common practices in the diagnosis and management of endogenous endophthalmitis.

Original languageEnglish (US)
Title of host publicationAlbert and Jakobiec's Principles and Practice of Ophthalmology
Subtitle of host publicationFourth Edition
PublisherSpringer International Publishing
Number of pages19
ISBN (Electronic)9783030426347
ISBN (Print)9783030426330
StatePublished - Jan 1 2022
Externally publishedYes


  • Bacteremia
  • Endogenous endophthalmitis
  • Hypopyon
  • Intravenous antibiotics
  • Sepsis

ASJC Scopus subject areas

  • General Medicine


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