TY - JOUR
T1 - Endovascular Repair of Blunt Thoracic Aortic Trauma is Associated with Increased Left Ventricular Mass, Hypertension, and Off-target Aortic Remodeling
AU - Kamenskiy, Alexey
AU - Aylward, Paul
AU - Desyatova, Anastasia
AU - Devries, Matthew
AU - Wichman, Christopher
AU - Mactaggart, Jason
N1 - Publisher Copyright:
© 2020 Wolters Kluwer Health, Inc. All rights reserved
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Background:Aortic elasticity creates a cushion that protects the heart from pressure injury, and a recoil that helps perfuse the coronary arteries. TEVAR has become first-line therapy for many aortic pathologies including trauma, but stent-grafts stiffen the aorta and likely increase LV afterload.Objective:Test the hypothesis that trauma TEVAR is associated with LV mass increase and adverse off-target aortic remodeling.Methods:Computed Tomography Angiography (CTA) scans of 20 trauma TEVAR patients (17 M/3 F) at baseline [age 34.9 ± 18.5 (11.4-71.5) years] and 5.1 ± 3.1 (1.1-12.3) years after repair were used to measure changes in LV mass, LV mass index, and diameters and lengths of the ascending thoracic aorta (ATA). Measurements were compared with similarly-aged control patients without aortic repair (21 M/21 F) evaluated at similar follow-ups.Results:LV mass and LV mass index of TEVAR patients increased from 138.5 ± 39.6 g and 72.35 ± 15.17 g/m2 to 173.5 ± 50.1 g and 85.48 ± 18.34 g/m2 at the rate of 10.03 ± 12.79 g/yr and 6.25 ± 10.28 g/m2/yr, whereas in control patients LV characteristics did not change. ATA diameters of TEVAR patients increased at a rate of 0.60 ± 0.80 mm/yr, which was 2.4-fold faster than in controls. ATA length in both TEVAR and control patients increased at 0.58 mm/yr. Half of TEVAR patients had hypertension at follow-up compared to only 5% at baseline.Conclusions:TEVAR is associated with LV mass increase, development of hypertension, and accelerated expansile remodeling of the ascending aorta. Although younger trauma patients may adapt to these effects, these changes may be even more important in older patients with other aortic pathologies and diminished baseline cardiac function.
AB - Background:Aortic elasticity creates a cushion that protects the heart from pressure injury, and a recoil that helps perfuse the coronary arteries. TEVAR has become first-line therapy for many aortic pathologies including trauma, but stent-grafts stiffen the aorta and likely increase LV afterload.Objective:Test the hypothesis that trauma TEVAR is associated with LV mass increase and adverse off-target aortic remodeling.Methods:Computed Tomography Angiography (CTA) scans of 20 trauma TEVAR patients (17 M/3 F) at baseline [age 34.9 ± 18.5 (11.4-71.5) years] and 5.1 ± 3.1 (1.1-12.3) years after repair were used to measure changes in LV mass, LV mass index, and diameters and lengths of the ascending thoracic aorta (ATA). Measurements were compared with similarly-aged control patients without aortic repair (21 M/21 F) evaluated at similar follow-ups.Results:LV mass and LV mass index of TEVAR patients increased from 138.5 ± 39.6 g and 72.35 ± 15.17 g/m2 to 173.5 ± 50.1 g and 85.48 ± 18.34 g/m2 at the rate of 10.03 ± 12.79 g/yr and 6.25 ± 10.28 g/m2/yr, whereas in control patients LV characteristics did not change. ATA diameters of TEVAR patients increased at a rate of 0.60 ± 0.80 mm/yr, which was 2.4-fold faster than in controls. ATA length in both TEVAR and control patients increased at 0.58 mm/yr. Half of TEVAR patients had hypertension at follow-up compared to only 5% at baseline.Conclusions:TEVAR is associated with LV mass increase, development of hypertension, and accelerated expansile remodeling of the ascending aorta. Although younger trauma patients may adapt to these effects, these changes may be even more important in older patients with other aortic pathologies and diminished baseline cardiac function.
KW - Blunt aortic trauma
KW - Hypertension
KW - Left ventricular mass
KW - Remodeling
KW - Stent-graft
KW - Ventricular-arterial coupling
KW - Windkessel
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U2 - 10.1097/SLA.0000000000003768
DO - 10.1097/SLA.0000000000003768
M3 - Article
C2 - 31904600
AN - SCOPUS:85095590393
SN - 0003-4932
VL - 274
SP - 1089
EP - 1098
JO - Annals of surgery
JF - Annals of surgery
IS - 6
ER -