Engineered Exosomes Containing Cathelicidin/LL-37 Exhibit Multiple Biological Functions

Yajuan Su, Navatha Shree Sharma, Johnson V. John, Gitali Ganguli-Indra, Arup K. Indra, Adrian F. Gombart, Jingwei Xie

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Exosomes show great potential in diagnostic and therapeutic applications. Inspired by the human innate immune defense, herein, we report engineered exosomes derived from monocytic cells treated with immunomodulating compounds 1α,25-dihydroxyvitamin D3, and CYP24A1 inhibitor VID400 which are slowly released from electrospun nanofiber matrices. These engineered exosomes contain significantly more cathelicidin/LL-37 when compared with exosomes derived from either untreated cells or Cathelicidin Human Tagged ORF Clone transfected cells. In addition, such exosomes exhibit multiple biological functions evidenced by killing bacteria, facilitating human umbilical vein endothelial cell tube formation, and enhancing skin cell proliferation and migration. Taken together, the engineered exosomes developed in this study can be used as therapeutics alone or in combination with other biomaterials for effective infection management, wound healing, and tissue regeneration.

Original languageEnglish (US)
Article number2200849
JournalAdvanced Healthcare Materials
Issue number20
StatePublished - Oct 19 2022


  • antibacterial property
  • engineered exosomes
  • immunomodulating compounds
  • nanofiber matrices
  • wound healing

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


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