TY - JOUR
T1 - Engineering antibodies for clinical applications
AU - Jain, Maneesh
AU - Kamal, Neel
AU - Batra, Surinder K.
N1 - Funding Information:
The authors were supported by grants from the National Institutes of Health (RO1 CA78590 and EDRN U01CA111294), the United States Department of Energy (DE-FG0295ER62024) and the Department of Defense (PC040502, OC04110). We also thank Kristi L. Berger for editing the manuscript.
PY - 2007/7
Y1 - 2007/7
N2 - Molecular engineering has contributed immensely to the clinical success of antibodies in recent years. The modular structure of antibodies has permitted their modification in numerous ways, to meet various clinical requirements. With the help of antibody engineering, it has been possible to modify the molecular size, pharmacokinetics, immunogenicity, binding affinity, specificity and effector function of antibodies. In addition, fusion proteins of antibodies with various proteins and peptides have yielded targeted biological modifiers, toxins and imaging agents. This review focuses on the recent trends in antibody engineering for improving their clinical utility.
AB - Molecular engineering has contributed immensely to the clinical success of antibodies in recent years. The modular structure of antibodies has permitted their modification in numerous ways, to meet various clinical requirements. With the help of antibody engineering, it has been possible to modify the molecular size, pharmacokinetics, immunogenicity, binding affinity, specificity and effector function of antibodies. In addition, fusion proteins of antibodies with various proteins and peptides have yielded targeted biological modifiers, toxins and imaging agents. This review focuses on the recent trends in antibody engineering for improving their clinical utility.
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U2 - 10.1016/j.tibtech.2007.05.001
DO - 10.1016/j.tibtech.2007.05.001
M3 - Review article
C2 - 17512622
AN - SCOPUS:34250177619
SN - 0167-7799
VL - 25
SP - 307
EP - 316
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 7
ER -