Engineering antibodies for clinical applications

Research output: Contribution to journalReview article

83 Scopus citations

Abstract

Molecular engineering has contributed immensely to the clinical success of antibodies in recent years. The modular structure of antibodies has permitted their modification in numerous ways, to meet various clinical requirements. With the help of antibody engineering, it has been possible to modify the molecular size, pharmacokinetics, immunogenicity, binding affinity, specificity and effector function of antibodies. In addition, fusion proteins of antibodies with various proteins and peptides have yielded targeted biological modifiers, toxins and imaging agents. This review focuses on the recent trends in antibody engineering for improving their clinical utility.

Original languageEnglish (US)
Pages (from-to)307-316
Number of pages10
JournalTrends in Biotechnology
Volume25
Issue number7
DOIs
StatePublished - Jul 2007

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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