Engineering hydrogel based cancer microenvironments for in vitro breast cancer cell culture and therapeutics screening

Wen Shi, Mitchell A. Kuss, Bhopal Mohapatra, Sameer Mirza, Hamid Band, Vimla Band, Bin Duan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Breast cancer cell of different invasiveness have been shown different morphologies and phenotypes when cultured inside various hydrogels1, 2. The commonly used 3D culture material-Matrigel suffers from issues such as batch to batch variation, complicated components and difficulty in stromal cell support. Type I collagen has offered an alternative to Matrigel for breast tumor culture, however, the morphology of breast cancer cells cultured in collagen is quite different from those in Matrigel. To solve such problem and better mimic the breast cancer microenvironment, we developed a novel collagen based hydrogel by mixing hyaluronic acid-poly (N-isopropylacrylamide) (HA-NIPAM) into collagen and evaluated the application of such hydrogel as a cancer microenvironment for in vitro breast cancer cell culture.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Shi, W., Kuss, M. A., Mohapatra, B., Mirza, S., Band, H., Band, V., & Duan, B. (2019). Engineering hydrogel based cancer microenvironments for in vitro breast cancer cell culture and therapeutics screening. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.