Enhanced photostability of ICG in close proximity to gold colloids

Chris D. Geddes, Haishi Cao, Joseph R. Lakowicz

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Photobleaching of fluorophores frequently limits their detectability or observation time. We examined Indocyanine green (ICG) which is widely used in medical testing and is highly unstable. We showed that spatial localization of ICG near metallic gold colloids resulted in increased photostability. This suggests the use of fluorophore-metal conjugates in situations adversely affected by photobleaching.

Original languageEnglish (US)
Pages (from-to)2611-2617
Number of pages7
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Issue number11
StatePublished - Sep 2003
Externally publishedYes


  • Fluorescence
  • Gold colloids
  • Indocyanine green
  • Photostability

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Spectroscopy


Dive into the research topics of 'Enhanced photostability of ICG in close proximity to gold colloids'. Together they form a unique fingerprint.

Cite this