Enhanced production of farnesol by Candida albicans treated with four azoles

Jacob M. Hornby, Kenneth W. Nickerson

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, fluconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans.

Original languageEnglish (US)
Pages (from-to)2305-2307
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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