Enhancement of ketoconazole penetration across the blood-brain barrier of mice by dimethyl sulfoxide

P. C. Iwen, N. G. Miller

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Mice were treated with ketoconazole with and without dimethyl sulfoxide. Concentrations of ketoconazole at 3 and 5 h after treatment were significantly higher in serum (P < 0.05) and brain tissue homogenate (P < 0.01) of mice treated with dimethyl sulfoxide than in those of mice not treated with diemthyl sulfoxide.

Original languageEnglish (US)
Pages (from-to)617-618
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume30
Issue number4
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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