Abstract
Objectives: A study was conducted to examine the in vitro cytotoxic effects of Echitamine chloride (EC), a plant alkaloid extracted from the bark of Alstonia scholaris. Since vitamin A was found to enhance the anticancer effects of several anticancer drugs, the synergistic effects of these two drugs were also studied. Methods: Echitamine chloride at a concentration of 200μM and Vitamin A at a concentration of 10 μM were added alone as well as in combination to the Ehrlich Ascites Carcinoma (EAC) cell cultures. Cell viability, antioxidant enzyme status, lipid peroxidation and 3H-Thymidine incorporation were studied. Results: The cultures treated with EC and vitamin A combination showed significant cytotoxic effect than the cultures treated with individual drugs. Conclusion: It may be concluded that EC in combination with vitamin A has an enhanced cytotoxic effect on Ehrlich Ascites Carcinoma cell culture.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 244-249 |
| Number of pages | 6 |
| Journal | Indian Journal of Pharmacology |
| Volume | 29 |
| Issue number | 4 |
| State | Published - 1997 |
Keywords
- Echitamine chloride
- Ehrlich ascites carcinoma
- H-Thymidine
- Incorporation
- Lipid peroxidation
- Vitamin A
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)