Enhancement of the cytotoxic effects of Echitamine chloride by vitamin A: An in vitro study on Ehrlich ascites carcinoma cell culture

S. Viswanathan, N. Ramamurthy, S. Subramanian, V. Mathuram, S. Govindasamy

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objectives: A study was conducted to examine the in vitro cytotoxic effects of Echitamine chloride (EC), a plant alkaloid extracted from the bark of Alstonia scholaris. Since vitamin A was found to enhance the anticancer effects of several anticancer drugs, the synergistic effects of these two drugs were also studied. Methods: Echitamine chloride at a concentration of 200μM and Vitamin A at a concentration of 10 μM were added alone as well as in combination to the Ehrlich Ascites Carcinoma (EAC) cell cultures. Cell viability, antioxidant enzyme status, lipid peroxidation and 3H-Thymidine incorporation were studied. Results: The cultures treated with EC and vitamin A combination showed significant cytotoxic effect than the cultures treated with individual drugs. Conclusion: It may be concluded that EC in combination with vitamin A has an enhanced cytotoxic effect on Ehrlich Ascites Carcinoma cell culture.

Original languageEnglish (US)
Pages (from-to)244-249
Number of pages6
JournalIndian Journal of Pharmacology
Volume29
Issue number4
StatePublished - 1997

Keywords

  • Echitamine chloride
  • Ehrlich ascites carcinoma
  • H-Thymidine
  • Incorporation
  • Lipid peroxidation
  • Vitamin A

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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