Enhancing siRNA effects in T cells for adoptive immunotherapy

Kevin Morris, Daniela Castanotto, Zaid Al-Kadhimi, Michael Jensen, John Rossi, Laurence J.N. Cooper

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Genetically manipulated T cells can be endowed with novel functions to obtain desired in vivo effects after adoptive transfer. This genetic approach is being used to introduce genes such as chimeric immunoreceptors and tumor-specific T cells are being evaluated in early phase clinic trials. However, the ability to alter the genetic programming of T cells also presents opportunities to remove unwanted T-cell functions in order to augment an anti-tumor effect or endow resistance such as to HIV infection. Specifically, the use of RNA interference (RNAi) to disrupt gene expression by targeting either the mRNA or the promoter, provides investigators with many new opportunities to genetically modify T cells that should prove useful in future applications of adoptive immunotherapy.

Original languageEnglish (US)
Pages (from-to)461-467
Number of pages7
JournalHematology
Volume10
Issue number6
DOIs
StatePublished - Dec 2005
Externally publishedYes

Keywords

  • Immunotherapy
  • RNA interference
  • T cells
  • siRNA

ASJC Scopus subject areas

  • Hematology

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