Enriching miRNA binding site specificity with sequence profile based filtering of 3'-UTR region of mRNA

Jasjit K. Banwait, Hesham Ali, Dhundy K. Bastola

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

MicroRNAs are small (approx. 22nt) noncoding RNAs that regulate gene expression by either degrading messenger-RNA (mRNA) that has already been transcribed or by repressing the translation of mRNA. This mechanism of gene regulation by binding of the miRNA to 3-prime-UTR of target mRNAs has been recently discovered and sequence-specific post-transcriptional gene regulation process affects large set of genes involved in number of biological pathways. Mapping of 7nt long miRNAseed sequence to the target gene has been a standard way of predicting miRNA targets. In this study, we have generated a profile-based filter to increase the specificity of human miRNA-mRNA relationship thereby enriching true-positive miRNA target sitesin humans based on sequence information.

Original languageEnglish (US)
Title of host publicationProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
Pages558-563
Number of pages6
DOIs
StatePublished - 2012
Event2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012 - Philadelphia, PA, United States
Duration: Oct 4 2012Oct 7 2012

Publication series

NameProceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012

Conference

Conference2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012
CountryUnited States
CityPhiladelphia, PA
Period10/4/1210/7/12

Keywords

  • gene regulation
  • miRNA
  • microRNA
  • non-coding RNAs
  • target prediction

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

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