@inproceedings{363fa9ca2943426d9182fda13fc0c7e0,
title = "Enriching miRNA binding site specificity with sequence profile based filtering of 3'-UTR region of mRNA",
abstract = "MicroRNAs are small (approx. 22nt) noncoding RNAs that regulate gene expression by either degrading messenger-RNA (mRNA) that has already been transcribed or by repressing the translation of mRNA. This mechanism of gene regulation by binding of the miRNA to 3-prime-UTR of target mRNAs has been recently discovered and sequence-specific post-transcriptional gene regulation process affects large set of genes involved in number of biological pathways. Mapping of 7nt long miRNAseed sequence to the target gene has been a standard way of predicting miRNA targets. In this study, we have generated a profile-based filter to increase the specificity of human miRNA-mRNA relationship thereby enriching true-positive miRNA target sitesin humans based on sequence information.",
keywords = "gene regulation, miRNA, microRNA, non-coding RNAs, target prediction",
author = "Banwait, {Jasjit K.} and Hesham Ali and Bastola, {Dhundy K.}",
year = "2012",
doi = "10.1109/BIBMW.2012.6470200",
language = "English (US)",
isbn = "9781467327466",
series = "Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012",
pages = "558--563",
booktitle = "Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012",
note = "2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012 ; Conference date: 04-10-2012 Through 07-10-2012",
}