TY - JOUR
T1 - Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virus-infected monkeys is associated with a unique cytokine environment
AU - Marcondes, Maria Cecilia G.
AU - Burdo, Tricia H.
AU - Sopper, Sieghart
AU - Huitron-Resendiz, Salvador
AU - Lanigan, Caroline
AU - Watry, Debbie
AU - Flynn, Claudia
AU - Zandonatti, Michelle
AU - Fox, Howard S.
PY - 2007/5/1
Y1 - 2007/5/1
N2 - The host reaction to infection of the brain contributes to a number of CNS pathologies including neuro-AIDS. In this study, we have identified the accumulation of SIV-specific CTL in the brains of SIV-infected animals who have neurophysiological abnormalities but are otherwise asymptomatic. SIV-specific CTL enter the brain early after viral infection and are maintained in the brain even when those reactive with an immunodominant epitope in Tat are lost from the rest of the body. The specialized CNS environment contributes to this unique outcome. Following SIV infection, brain levels of IL-15 were significantly elevated whereas IL-2 was absent, creating an environment that favors CTL persistence. Furthermore, in response to IL-15, brain-derived CB8+ T cells could expand in greater numbers than those from spleen. The accumulation, persistence, and maintenance of CTL in the brain are closely linked to the increased levels of IL-15 in the absence of IL-2 in the CNS following SIV infection.
AB - The host reaction to infection of the brain contributes to a number of CNS pathologies including neuro-AIDS. In this study, we have identified the accumulation of SIV-specific CTL in the brains of SIV-infected animals who have neurophysiological abnormalities but are otherwise asymptomatic. SIV-specific CTL enter the brain early after viral infection and are maintained in the brain even when those reactive with an immunodominant epitope in Tat are lost from the rest of the body. The specialized CNS environment contributes to this unique outcome. Following SIV infection, brain levels of IL-15 were significantly elevated whereas IL-2 was absent, creating an environment that favors CTL persistence. Furthermore, in response to IL-15, brain-derived CB8+ T cells could expand in greater numbers than those from spleen. The accumulation, persistence, and maintenance of CTL in the brain are closely linked to the increased levels of IL-15 in the absence of IL-2 in the CNS following SIV infection.
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U2 - 10.4049/jimmunol.178.9.5812
DO - 10.4049/jimmunol.178.9.5812
M3 - Article
C2 - 17442965
AN - SCOPUS:34247626328
VL - 178
SP - 5812
EP - 5819
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 9
ER -