Abstract
Findings of pancreatitis in mice after infection with the human enteroviruses coxsackievirus B (CVB) suggested a relationship to the onset of type 1 diabetes (Coleman et al. 1973), a correlation that had been suggested by studies that had variably found a serologic relationship of CVB4 to recent onset diabetic patients (Gamble et al. 1969). Although other enteroviruses may well be involved in induction of pancreatitis and type 1 diabetes (Tracy et al. 2010), the ability of CVBs to use the murine homolog of the coxsackievirus and adenovirus receptor CAR (Bergelson et al. 1997; Carson et al. 1997; Tomko et al. 1997; Bergelson et al. 1998) makes CVB-induced murine pancreatitis and diabetes a model for the human disease.
Original language | English (US) |
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Title of host publication | Diabetes and Viruses |
Publisher | Springer New York |
Pages | 49-56 |
Number of pages | 8 |
Volume | 9781461440512 |
ISBN (Electronic) | 9781461440512 |
ISBN (Print) | 1461440505, 9781461440505 |
DOIs | |
State | Published - Mar 1 2013 |
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)