Abstract
Findings of pancreatitis in mice after infection with the human enteroviruses coxsackievirus B (CVB) suggested a relationship to the onset of type 1 diabetes (Coleman et al. 1973), a correlation that had been suggested by studies that had variably found a serologic relationship of CVB4 to recent onset diabetic patients (Gamble et al. 1969). Although other enteroviruses may well be involved in induction of pancreatitis and type 1 diabetes (Tracy et al. 2010), the ability of CVBs to use the murine homolog of the coxsackievirus and adenovirus receptor CAR (Bergelson et al. 1997; Carson et al. 1997; Tomko et al. 1997; Bergelson et al. 1998) makes CVB-induced murine pancreatitis and diabetes a model for the human disease.
| Original language | English (US) |
|---|---|
| Title of host publication | Diabetes and Viruses |
| Publisher | Springer New York |
| Pages | 49-56 |
| Number of pages | 8 |
| Volume | 9781461440512 |
| ISBN (Electronic) | 9781461440512 |
| ISBN (Print) | 1461440505, 9781461440505 |
| DOIs | |
| State | Published - Mar 1 2013 |
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
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Cite this
Chapman, N. M. (2013). Enteroviruses in the mouse model of type 1 diabetes. In Diabetes and Viruses (Vol. 9781461440512, pp. 49-56). Springer New York. https://doi.org/10.1007/978-1-4614-4051-2_6