Envelope protein Us9 is required for the anterograde transport of bovine herpesvirus type 1 from trigeminal ganglia to nose and eye upon reactivation

N. B. Butchi, C. Jones, S. Perez, A. Doster, S. I. Chowdhury

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

In this study, the authors examined the role of bovine herpesvirus type 1 (BHV-1) Us9 in the anterograde transport of the virus from trigeminal ganglia (TG) to nose and eye upon reactivation from latency. During primary infection, both BHV-1 Us9-deleted and BHV-1 Us9-rescued viruses replicated efficiently in the nasal and ocular epithelium. However, upon reactivation from latency, only the BHV-1 Us9-rescued virus could be isolated in the nasal and ocular shedding. By real-time polymerase chain reaction, comparable DNA copy numbers were detected in the TGs during latency and reactivation for both the viruses. Therefore, Us9 is essential for reactivation of the virus in the TG and anterograde axonal transport from TG to nose and eye.

Original languageEnglish (US)
Pages (from-to)384-388
Number of pages5
JournalJournal of neurovirology
Volume13
Issue number4
DOIs
StatePublished - Jul 2007

Keywords

  • Anterograde neuronal transport
  • BHV-1 envelope protein Us9
  • Latency and reactivation
  • Trigeminal ganglia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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