Environmental toxicity, oxidative stress and apoptosis: Ménage à Trois

Rodrigo Franco, Roberto Sánchez-Olea, Elsa M. Reyes-Reyes, Mihalis I. Panayiotidis

Research output: Contribution to journalReview articlepeer-review

359 Scopus citations


Apoptosis is an evolutionary conserved homeostatic process involved in distinct physiological processes including organ and tissue morphogenesis, development and senescence. Its deregulation is also known to participate in the etiology of several human diseases including cancer, neurodegenerative and autoimmune disorders. Environmental stressors (cytotoxic agents, pollutants or toxicants) are well known to induce apoptotic cell death and to contribute to a variety of pathological conditions. Oxidative stress seems to be the central element in the regulation of the apoptotic pathways triggered by environmental stressors. In this work, we review the established mechanisms by which oxidative stress and environmental stressors regulate the apoptotic machinery with the aim to underscore the relevance of apoptosis as a component in environmental toxicity and human disease progression.

Original languageEnglish (US)
Pages (from-to)3-22
Number of pages20
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Issue number1-2
StatePublished - Mar 31 2009
Externally publishedYes


  • Asbestos
  • Cell death
  • Cigarette smoke
  • DNA damage
  • Dioxins
  • Endoplasmic reticulum stress
  • Environmental agents
  • Environmental stress
  • Environmental toxicants
  • Free radicals
  • Glutathione
  • Ionizing radiation
  • MAPK
  • Metals
  • Oxidative stress
  • Particulate matter
  • Pesticides
  • ROS
  • SAPK
  • Ultraviolet radiation
  • p53

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Environmental toxicity, oxidative stress and apoptosis: Ménage à Trois'. Together they form a unique fingerprint.

Cite this