Environmental Triggers of Hyperuricemia and Gout

Lindsay N. Helget, Ted R. Mikuls

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Gout is the most prevalent type of inflammatory arthritis worldwide and environmental factors contribute to hyperuricemia and risk for gout flare. Causes of hyperuricemia include increased purine consumption from meat, alcohol, and high fructose corn syrup as well as medications such as cyclosporine, low-dose aspirin, or diuretics. Triggers for gout flares include increased purine consumption and medication use such as urate lowering therapy and diuretics. Environmental exposures including lead exposure, particulate matter exposure, temperature fluctuations, and physiologic stress have been found to trigger flares. In the right clinical scenario, these factors should be considered when treating gout patients.

Original languageEnglish (US)
Pages (from-to)891-906
Number of pages16
JournalRheumatic Disease Clinics of North America
Issue number4
StatePublished - Nov 2022


  • Diet
  • Environmental exposures
  • Epidemiology
  • Gout
  • Hyperuricemia

ASJC Scopus subject areas

  • Rheumatology


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