Enzymatic resolution of racemic glycals: an application of the wong acylation method

David B. Berkowitz, Samuel J. Danishefsky

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Kinetic resolution of racemic, fully synthetic, artificial glycals bearing a free hydroxyl group at C3 was accomplished through the more rapid acylation of the "D"-antipode with vinyl acetate as acyl donor and Lipase PS-30 from Pseudomonas cepacia as catalyst.

Original languageEnglish (US)
Pages (from-to)5497-5500
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number40
DOIs
StatePublished - Sep 30 1991

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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