Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs

Haruhito Sugiyama; Ryosuke Eda; Chiharu Okada; Russell J. Hopp; Againdra K. Bewtra; Robert G. Townley

doi:10.3109/02770909509089498

Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs

Haruhito Sugiyama, Ryosuke Eda, Chiharu Okada, Russell J. Hopp, Againdra K. Bewtra, Robert G. Townley

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.

Original language	English (US)
Pages (from-to)	37-45
Number of pages	9
Journal	Journal of Asthma
Volume	32
Issue number	1
DOIs	https://doi.org/10.3109/02770909509089498
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Pulmonary and Respiratory Medicine

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10.3109/02770909509089498

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abstract = "The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.",

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AU - Bewtra, Againdra K.

AU - Townley, Robert G.

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N2 - The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.

AB - The purpose of this study was to investigate the participation of airway eosinophils in the antigen-induced late asthmatic response (LAR) and increased airway responsiveness in the guinea pig model of asthma. After antigen challenge, guinea pigs sensitized with aerosolized ovalbumin showed a late-phase decrease in specific airway conductance, which was accompanied by airway hyperresponsiveness to histamine, eosinophilia in the bronchoalveolar lavage fluid (BALF), decreased BALF eosinophil density, and increased generation of superoxide anions from purified BALF eosinophils. We demonstrated an association of the LAR with eosinophil accumulation and activation in the airway.

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Eosinophil accumulation and activation in antigen-induced late asthmatic response in Guinea pigs

Abstract

ASJC Scopus subject areas

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