TY - CHAP
T1 - EPCES and EPSVR
T2 - Prediction of B-Cell antigenic epitopes on protein surfaces with conformational information
AU - Liang, Shide
AU - Zheng, Dandan
AU - Yao, Bo
AU - Zhang, Chi
N1 - Funding Information:
The work is supported by funding under C.Z.’s startup funds from the University of Nebraska, Lincoln, NE. This work was completed utilizing the Holland Computing Center of the University of Nebraska.
Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2020.
PY - 2020
Y1 - 2020
N2 - Accurate prediction of discontinuous antigenic epitopes is important for immunologic research and medical applications, but it is not an easy problem. Currently, there are only a few prediction servers available, though discontinuous epitopes constitute the majority of all B-cell antigenic epitopes. In this chapter, we describe two online servers, EPCES and EPSVR, for discontinuous epitope prediction. All methods were benchmarked by a curated independent test set, in which all antigens had no complex structures with the antibody, and their epitopes were identified by various biochemical experiments. The servers and all datasets are available at http://sysbio.unl.edu/EPCES/ and http://sysbio.unl.edu/EPSVR/.
AB - Accurate prediction of discontinuous antigenic epitopes is important for immunologic research and medical applications, but it is not an easy problem. Currently, there are only a few prediction servers available, though discontinuous epitopes constitute the majority of all B-cell antigenic epitopes. In this chapter, we describe two online servers, EPCES and EPSVR, for discontinuous epitope prediction. All methods were benchmarked by a curated independent test set, in which all antigens had no complex structures with the antibody, and their epitopes were identified by various biochemical experiments. The servers and all datasets are available at http://sysbio.unl.edu/EPCES/ and http://sysbio.unl.edu/EPSVR/.
KW - B-cell epitope prediction
KW - Support vector machine
UR - http://www.scopus.com/inward/record.url?scp=85081934846&partnerID=8YFLogxK
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U2 - 10.1007/978-1-0716-0389-5_16
DO - 10.1007/978-1-0716-0389-5_16
M3 - Chapter
C2 - 32162262
AN - SCOPUS:85081934846
T3 - Methods in Molecular Biology
SP - 289
EP - 297
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -