Epidermal growth factor inhibition in solid tumours

Apar Kishor Ganti, Anil Potti

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

The epidermal growth factor receptor (EGFR) plays an important role in the carcinogenesis of many human malignancies and is therefore an attractive target against which anticancer therapy may be effective. At present, there are two ways in which this may be achieved clinically: antibodies against EGFR and inhibitors of the EGFR tyrosine kinase. This review describes presently approved agents cetuximab (monoclonal EGFR antibody), gefitinib and erlotinib (EGFR tyrosine kinase inhibitors) in detail. Efficacy data for these agents in various human malignancies is presented. Various other agents that are in the early stages of development at present have also been mentioned.

Original languageEnglish (US)
Pages (from-to)1165-1174
Number of pages10
JournalExpert Opinion on Biological Therapy
Volume5
Issue number9
DOIs
StatePublished - Sep 2005

Keywords

  • Cetuximab
  • EGFR antibodies
  • EGFR inhibitors
  • EGFR tyrosine kinase inhibitors
  • Erlotinib
  • Gefitinib

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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