Epigenetic alterations fuel brain metastasis via regulating inflammatory cascade

Shailendra Kumar Maurya, Asad Ur Rehman, Mohd Ali Abbas Zaidi, Parvez Khan, Shailendra K. Gautam, Juan A. Santamaria-Barria, Jawed Akhtar Siddiqui, Surinder K. Batra, Mohd Wasim Nasser

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Brain metastasis (BrM) is a major threat to the survival of melanoma, breast, and lung cancer patients. Circulating tumor cells (CTCs) cross the blood-brain barrier (BBB) and sustain in the brain microenvironment. Genetic mutations and epigenetic modifications have been found to be critical in controlling key aspects of cancer metastasis. Metastasizing cells confront inflammation and gradually adapt in the unique brain microenvironment. Currently, it is one of the major areas that has gained momentum. Researchers are interested in the factors that modulate neuroinflammation during BrM. We review here various epigenetic factors and mechanisms modulating neuroinflammation and how this helps CTCs to adapt and survive in the brain microenvironment. Since epigenetic changes could be modulated by targeting enzymes such as histone/DNA methyltransferase, deacetylases, acetyltransferases, and demethylases, we also summarize our current understanding of potential drugs targeting various aspects of epigenetic regulation in BrM.

Original languageEnglish (US)
Pages (from-to)261-274
Number of pages14
JournalSeminars in Cell and Developmental Biology
Volume154
DOIs
StateAccepted/In press - 2022

Keywords

  • Brain metastasis
  • Brain microenvironment
  • Epigenetics regulation
  • Inflammation
  • Inflammatory cascade

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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