Epigenetic changes in BRCA1-mutated familial breast cancer

Bradley Downs, San Ming Wang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Familialbreast cancer occurs in about 10% of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. Mutated BRCA1 leads to disease by causing genome instability via multiple mechanisms including epigenetic changes. This review summarizes recent progress in studying the correlation between BRCA1 predisposition and epigenetic alterations in BRCA1-type familial breast cancer.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalCancer Genetics
Issue number5
StatePublished - May 1 2015


  • Autosomal dominant
  • BRCA1
  • Epigenetic alteration
  • Familial breast cancer
  • Germline mutation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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