Epigenetic regulation of bone remodeling and bone metastasis

Gunjan Sharma, Ashrafi Sultana, K. M. Abdullah, Ramesh Pothuraju, Mohd Wasim Nasser, Surinder Kumar Batra, Jawed Akhtar Siddiqui

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Bone remodeling is a continuous and dynamic process of bone formation and resorption to maintain its integrity and homeostasis. Bone marrow is a source of various cell lineages, including osteoblasts and osteoclasts, which are involved in bone formation and resorption, respectively, to maintain bone homeostasis. Epigenetics is one of the elementary regulations governing the physiology of bone remodeling. Epigenetic modifications, mainly DNA methylation, histone modifications, and non-coding RNAs, regulate stable transcriptional programs without causing specific heritable alterations. DNA methylation in CpG-rich promoters of the gene is primarily correlated with gene silencing, and histone modifications are associated with transcriptional activation/inactivation. However, non-coding RNAs regulate the metastatic potential of cancer cells to metastasize at secondary sites. Deregulated or altered epigenetic modifications are often seen in many cancers and interwound with bone-specific tropism and cancer metastasis. Histone acetyltransferases, histone deacetylase, and DNA methyltransferases are promising targets in epigenetically altered cancer. High throughput epigenome mapping and targeting specific epigenetics modifiers will be helpful in the development of personalized epi-drugs for advanced and bone metastasis cancer patients. This review aims to discuss and gather more knowledge about different epigenetic modifications in bone remodeling and metastasis. Further, it provides new approaches for targeting epigenetic changes and therapy research.

Original languageEnglish (US)
Pages (from-to)275-285
Number of pages11
JournalSeminars in Cell and Developmental Biology
Volume154
DOIs
StatePublished - Feb 15 2024

Keywords

  • Acetylation
  • And Bone metastasis
  • Bone remodeling
  • Circular RNA
  • DNA methylation
  • Epigenetic modification
  • Histone modifications
  • Long non-coding RNA
  • MicroRNA
  • Non-coding RNA

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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