Epigenetics of inflammation, maternal infection, and nutrition

Kate J. Claycombe, Catherine A. Brissette, Othman Ghribi

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Studies have demonstrated that epigenetic changes such as DNA methylation, histone modification, and chromatin remodeling are linked to an increased inflammatory response as well as increased risk of chronic disease development. A few studies have begun to investigate whether dietary nutrients play a beneficial role by modifying or reversing epigenetically induced inflammation. Results of these studies show that nutrients modify epigenetic pathways. However, little is known about how nutrients modulate inflammation by regulating immune cell function and/or immune cell differentiation via epigenetic pathways. This overview will provide information about the current understanding of the role of nutrients in the epigenetic control mechanisms of immune function.

Original languageEnglish (US)
Pages (from-to)1109S-1115S
JournalJournal of Nutrition
Volume145
Issue number5
DOIs
StatePublished - Jan 1 2015

Keywords

  • Epigenetics
  • Immunity
  • Inflammation
  • Macrophages
  • Nutrients
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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