Epistatic interaction between COMT and DAT1 genes on eating behavior: A pilot study

Samantha L. Hersrud; Scott F. Stoltenberg

doi:10.1016/j.eatbeh.2009.01.003

Epistatic interaction between COMT and DAT1 genes on eating behavior: A pilot study

Samantha L. Hersrud, Scott F. Stoltenberg

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Problems related to food and weight in women may be influenced by the (DA) dopamine system. Catechol-o-methyl transferase (COMT) and the dopamine transporter (DAT) exert control on concentrations of extracellular DA. High and low functioning alleles of the COMT Val158Met and DAT1 3' UTR VNTR polymorphisms have been identified, and their associations with reward and cognition suggest a role in the modulation of eating behavior. A sample of undergraduate college women (N = 71) was characterized for binge eating and eating psychopathology and genotyped for the COMT and DAT1 markers. Results revealed a significant epistatic interaction between COMT and DAT1 genes on eating psychopathology and binge eating (p = .02 for both). This suggests that genetic studies of risk for maladaptive eating behavior involving the dopamine system should explicitly consider epistasis.

Original language	English (US)
Pages (from-to)	131-133
Number of pages	3
Journal	Eating Behaviors
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/j.eatbeh.2009.01.003
State	Published - Apr 2009
Externally published	Yes

Keywords

Catechol-o-methyl transferase
Dopamine transporter
Eating disorders
Epistasis

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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10.1016/j.eatbeh.2009.01.003

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title = "Epistatic interaction between COMT and DAT1 genes on eating behavior: A pilot study",

abstract = "Problems related to food and weight in women may be influenced by the (DA) dopamine system. Catechol-o-methyl transferase (COMT) and the dopamine transporter (DAT) exert control on concentrations of extracellular DA. High and low functioning alleles of the COMT Val158Met and DAT1 3' UTR VNTR polymorphisms have been identified, and their associations with reward and cognition suggest a role in the modulation of eating behavior. A sample of undergraduate college women (N = 71) was characterized for binge eating and eating psychopathology and genotyped for the COMT and DAT1 markers. Results revealed a significant epistatic interaction between COMT and DAT1 genes on eating psychopathology and binge eating (p = .02 for both). This suggests that genetic studies of risk for maladaptive eating behavior involving the dopamine system should explicitly consider epistasis.",

keywords = "Catechol-o-methyl transferase, Dopamine transporter, Eating disorders, Epistasis",

author = "Hersrud, {Samantha L.} and Stoltenberg, {Scott F.}",

note = "Funding Information: This study was made possible by NIH Grant Number 2 P20 RR016479 and 1 R15MH077654-01A1.",

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doi = "10.1016/j.eatbeh.2009.01.003",

language = "English (US)",

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journal = "Eating Behaviors",

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T2 - A pilot study

AU - Hersrud, Samantha L.

AU - Stoltenberg, Scott F.

N1 - Funding Information: This study was made possible by NIH Grant Number 2 P20 RR016479 and 1 R15MH077654-01A1.

PY - 2009/4

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N2 - Problems related to food and weight in women may be influenced by the (DA) dopamine system. Catechol-o-methyl transferase (COMT) and the dopamine transporter (DAT) exert control on concentrations of extracellular DA. High and low functioning alleles of the COMT Val158Met and DAT1 3' UTR VNTR polymorphisms have been identified, and their associations with reward and cognition suggest a role in the modulation of eating behavior. A sample of undergraduate college women (N = 71) was characterized for binge eating and eating psychopathology and genotyped for the COMT and DAT1 markers. Results revealed a significant epistatic interaction between COMT and DAT1 genes on eating psychopathology and binge eating (p = .02 for both). This suggests that genetic studies of risk for maladaptive eating behavior involving the dopamine system should explicitly consider epistasis.

AB - Problems related to food and weight in women may be influenced by the (DA) dopamine system. Catechol-o-methyl transferase (COMT) and the dopamine transporter (DAT) exert control on concentrations of extracellular DA. High and low functioning alleles of the COMT Val158Met and DAT1 3' UTR VNTR polymorphisms have been identified, and their associations with reward and cognition suggest a role in the modulation of eating behavior. A sample of undergraduate college women (N = 71) was characterized for binge eating and eating psychopathology and genotyped for the COMT and DAT1 markers. Results revealed a significant epistatic interaction between COMT and DAT1 genes on eating psychopathology and binge eating (p = .02 for both). This suggests that genetic studies of risk for maladaptive eating behavior involving the dopamine system should explicitly consider epistasis.

KW - Catechol-o-methyl transferase

KW - Dopamine transporter

KW - Eating disorders

KW - Epistasis

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Epistatic interaction between COMT and DAT1 genes on eating behavior: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

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