Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation

Marcie R. Kritzik, Cory U. Lago, Ayse G. Kayali, Sandrine Arnaud-Dabernat, Guoxun Liu, You Qing Zhang, Hong Hua, Howard S. Fox, Nora E. Sarvetnick

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.

Original languageEnglish (US)
Pages (from-to)312-321
Number of pages10
JournalEndocrine
Volume37
Issue number2
DOIs
StatePublished - Apr 2010

Keywords

  • CXCR4
  • Intestine
  • Pancreas
  • Regeneration
  • SDF1

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Kritzik, M. R., Lago, C. U., Kayali, A. G., Arnaud-Dabernat, S., Liu, G., Zhang, Y. Q., Hua, H., Fox, H. S., & Sarvetnick, N. E. (2010). Epithelial progenitor 1, a novel factor associated with epithelial cell growth and differentiation. Endocrine, 37(2), 312-321. https://doi.org/10.1007/s12020-009-9297-5