Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt

Josée Audouin, Jacques Diebold, Bharat Nathwani, Elia Ishak, Kenneth MacLennan, Hans Konrad Mueller-Hermelink, James O. Armitage, Dennis D. Weisenburger

Research output: Contribution to journalArticle

15 Scopus citations


Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed-Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalJournal of Hematopathology
Issue number1
StatePublished - Jun 1 2010


  • Classic Hodgkin's lymphoma
  • EBER-1
  • Epstein-Barr virus
  • LMP-1
  • Nodular lymphocyte predominant Hodgkin's lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

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  • Cite this

    Audouin, J., Diebold, J., Nathwani, B., Ishak, E., MacLennan, K., Mueller-Hermelink, H. K., Armitage, J. O., & Weisenburger, D. D. (2010). Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt. Journal of Hematopathology, 3(1), 11-18. https://doi.org/10.1007/s12308-010-0059-3